Endocrine Abstracts

We have already reported that synthetic analogs of 3-iodothyronamine (T1AM), a naturally occurring thyroid hormone derivative, share a pleiotropic activity with the endogenous parent compound, including autophagic flux promotion (ATG), neuroprotection, and metabolic reprogramming. Our study aimed to determine whether the T1AM lead analog SG2 and its derivatives SG22 and SG23, developed as prodrugs of SG2, can protect human glioblastoma U87 MG cells from the toxic effects induc...